Blar i forfatter "Skalko Basnet, Natasa"

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    • Liposomes - Human phagocytes interplay in whole blood: effect of liposome design 

      Giambelluca, Miriam Soledad; Markova, Elena; Louet, Claire; Steinkjer, Bjørg; Sundset, Rune; Skalko Basnet, Natasa; Hak, Sjoerd (Journal article; Tidsskriftartikkel, 2023-10-20)
      Nanomedicine holds immense potential for therapeutic manipulation of phagocytic immune cells. However, in vitro studies often fail to accurately translate to the complex in vivo environment. To address this gap, we employed an ex vivo human whole-blood assay to evaluate liposome interactions with immune cells. We systematically varied liposome size, PEG-surface densities and sphingomyelin and ...

    • Polymyxin B stabilized DNA micelles for sustained antibacterial and antibiofilm activity against P. aeruginosa 

      Antunes de Sousa, Alexandra Sofia; Borøy, Vegard; Bæverud, Agnethe Hansen; Julin, Kjersti; Bayer, Annette; Strøm, Morten B.; Johannessen, Mona Susan; Skalko Basnet, Natasa; Obuobi, Sybil Akua Okyerewa (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-21)
      Nucleic acid-based materials showcase an increasing potential for antimicrobial drug delivery. Although numerous reports on drug-loaded DNA nanoparticles outline their pivotal antibacterial activities, their potential as drug delivery systems against bacterial biofilms awaits further studies. Among different oligonucleotide structures, micellar nanocarriers derived from amphiphilic DNA strands ...